Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.54 |
| ▸ | FPR3 | P25089 | 2/20 | 0.53 |
| ▸ | TSPO | P30536 | 2/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845362 | 0.81 | CRHR1 (0.56) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5844050 | 0.77 | CRHR1 (0.55) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL7436165 | 0.77 | CRHR1 (0.53) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5600368 | 0.77 | CRHR1 (0.54) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5599808 | 0.77 | CRHR1 (0.53) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6290354 | 0.76 | CRHR1 (0.52) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5845706 | 0.74 | CRHR1 (0.56) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5600404 | 0.74 | CRHR1 (0.53) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5599412 | 0.73 | CRHR1 (0.51) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5844703 | 0.72 | CRHR1 (0.54) | CRHR1FPR3TSPOTMEM97TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |