Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426931 | 0.90 | MAPT (0.48) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL5049894 | 0.77 | ELANE (0.64) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL6444746 | 0.73 | RAD51 (0.50) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL6427000 | 0.72 | NR1H2 (0.60) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL6431729 | 0.72 | NR1H2 (0.51) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL8133525 | 0.71 | ELANE (0.61) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL6426236 | 0.71 | MAPT (0.46) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL6442280 | 0.71 | MAPT (0.46) | MAPTMAPK1KDM4ETP53HPGD | |
| SCHEMBL6429398 | 0.70 | NPSR1 (0.41) | MAPTMAPK1HPGDALDH1A1L3MBTL1 | |
| SCHEMBL15437828 | 0.70 | NR1H2 (0.70) | ALDH1A1MEN1KMT2ANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005024755-A2 | MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2005-03-17 | — | — | WO | disclosed |