Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.54 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.54 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | BLM | P54132 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL7510435 | 1.00 | — | — | |
| Ethylenediamine SCHEMBL28229848 | 1.00 | GLRA1 (0.54) | GLRA1SLC6A9OR51E2CA1CA2 | |
| Ethylenediamine SCHEMBL10815460 | 1.00 | GLRA1 (0.54) | GLRA1SLC6A9OR51E2CA1CA2 | |
| Ethylenediamine SCHEMBL909940 | 1.00 | GLRA1 (0.54) | GLRA1SLC6A9OR51E2CA1CA2 | |
| Ethylenediamine SCHEMBL28793643 | 0.95 | — | — | |
| Ethylenediamine SCHEMBL28793642 | 0.95 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2CA1CA2 | |
| Ethylenediamine SCHEMBL28314045 | 0.95 | — | — | |
| Ethylenediamine SCHEMBL2565448 | 0.91 | GLRA1 (0.47) | GLRA1SLC6A9OR51E2CA1CA2 | |
| Acetic Acid SCHEMBL6009228 | 0.88 | FFAR3 (0.54) | GLRA1SLC6A9OR51E2CA1CA2 | |
| Carbamic Acid SCHEMBL974051 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578507-B1 | Cleaning solutions including nucleophilic amine compound having reduction and oxidation potentials | EKC TECHNOLOGY INC (US) | 2005-09-28 | — | — | EP | claimed |
| EP-0753530-B1 | Dispersions of strengthened rubber, their preparation and use | POLYMER LATEX GMBH & CO KG (DE) | 1999-08-04 | — | — | EP | disclosed |
| EP-0753530-A2 | Dispersions of strengthened rubber, their preparation and use | HÜLS AKTIENGESELLSCHAFT (DE) | 1997-01-15 | — | — | EP | disclosed |