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SCHEMBL6428822

SCHEMBL6428822

O=C(Nc1ccc2ccc(S(=O)(=O)O)cc2c1)Nc1ccc2ccc(S(=O)(=O)Nc3ccc(S(=O)(=O)O)cc3)cc2c1

nearest known ligand 0.75

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PRMT1 Q99873 1/20 0.56
▸ ALDH1A1 P00352 1/20 0.52
▸ LMNA P02545 1/20 0.52
▸ GAA P10253 1/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ CA2 P00918 1/20 0.51
▸ TIMP3 P35625 1/20 0.50
▸ ATM Q13315 1/20 0.50
▸ PGR P06401 1/20 0.48
▸ IDH1 O75874 1/20 0.47
▸ PLAU P00749 1/20 0.47
▸ HDAC1 Q13547 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6078234 0.99 PRMT1 (0.54) PRMT1ALDH1A1LMNAGAASMN1; SMN2
SCHEMBL6079075 0.93 ALDH1A1 (0.62) ALDH1A1LMNAGAASMN1; SMN2CA2
SCHEMBL6078797 0.89 PRMT1 (0.67) PRMT1CA2TIMP3
SCHEMBL6078748 0.89 PRMT1 (0.67) PRMT1CA2TIMP3
SCHEMBL6079410 0.89 MEN1 (0.55) PRMT1LMNASMN1; SMN2CA2IDH1
SCHEMBL6079569 0.89 MEN1 (0.55) PRMT1LMNASMN1; SMN2CA2IDH1
SCHEMBL6078878 0.89 MEN1 (0.55) PRMT1LMNASMN1; SMN2CA2IDH1
SCHEMBL6078621 0.89 MEN1 (0.55) PRMT1LMNASMN1; SMN2CA2IDH1
SCHEMBL6079560 0.88 MEN1 (0.54) PRMT1LMNASMN1; SMN2CA2IDH1
SCHEMBL6078869 0.88 MEN1 (0.54) PRMT1LMNASMN1; SMN2CA2IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1181271-B1 NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS TELIK INC (US) 2005-01-19 — — EP disclosed