Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SORD | Q00796 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22481379 | 0.77 | TRPC3 (0.75) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL7848240 | 0.76 | TRPC3 (0.73) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL13450331 | 0.76 | TRPC3 (1.00) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL2674037 | 0.73 | BCHE (0.90) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL2676103 | 0.73 | BCHE (0.96) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL5309716 | 0.72 | BCHE (0.71) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL9369695 | 0.72 | TRPC3 (0.68) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL4713162 | 0.72 | TRPC3 (0.68) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL717865 | 0.72 | BCHE (1.00) | TRPC3BCHEACHEHTR3ATP53 | |
| SCHEMBL2241920 | 0.72 | BCHE (1.00) | TRPC3BCHEACHEHTR3ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235565-B1 | USE OF 5HT 3 AGONISTS FOR RELAXING THE FUNDUS | JANSSEN PHARMACEUTICA NV (BE) | 2005-12-28 | — | — | EP | disclosed |
| US-20050209270-A1 | Use of 5HT3 agonists for relaxing the fundus | MEULEMANS ANN LOUISE G | 2005-09-22 | — | — | US | disclosed |
| US-20050119297-A1 | Use of 5HT3 agonists for relaxing the fundus | MEULEMANS ANN L G (BE) | 2005-06-02 | — | — | US | disclosed |