Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 1.00 |
| ▸ | ACHE | P22303 | 2/20 | 1.00 |
| ▸ | HTR3A | P46098 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 3/20 | 0.71 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | GFER | P55789 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SORD | Q00796 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717865 | 1.00 | BCHE (1.00) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL2676103 | 0.98 | BCHE (0.96) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL2674037 | 0.95 | BCHE (0.90) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL8880315 | 0.88 | HTR3A (0.82) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL3075702 | 0.85 | HTR3A (0.88) | BCHEACHEHTR3ATP53TRPC3 | |
| Bromide SCHEMBL6599072 | 0.84 | HTR3A (0.85) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL25809621 | 0.84 | BCHE (0.72) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL531762 | 0.84 | HTR3A (1.00) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL4674485 | 0.84 | BCHE (0.73) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL2674838 | 0.83 | TP53 (1.00) | BCHEACHEHTR3ATP53TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101600717-B | 2- piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives | JANSSEN PHARMACEUTICA NV | 2013-03-13 | — | — | CN | disclosed |
| EP-2121683-B1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-08-31 | — | — | EP | disclosed |
| US-7994173-B2 | 2-piperazin-1-yl-3H-imidazo[4,5-b]pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-09 | — | — | US | disclosed |
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | US | disclosed |
| CN-101600717-A | 2-piperazine-1-base-3H-imidazo [4,5-B] pyridine derivate | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-09 | — | — | CN | disclosed |
| EP-2121683-A2 | 2- PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | Janssen Pharmaceutica, N.V. (BE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008090200-A2 | 2- PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2008-07-31 | — | — | WO | disclosed |
| US-7304052-B2 | Substituted homopiperidinyl benzimidazole analogues as fundic relaxants | JANSSEN PHARMACEUITCA N.V. (BE) | 2007-12-04 | — | — | US | disclosed |
| CN-100343251-C | Substituted homopiperidinyl benzimidazole compounds, pharmaceutical compositions containing them, process for preparing them and their use as medicaments | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-17 | — | — | CN | disclosed |
| CN-100343251-C | Substituted homopiperidinyl benzimidazole compounds, pharmaceutical compositions containing them, process for preparing them and their use as medicaments | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-17 | — | — | CN | disclosed |
| US-20030139393-A1 | Substituted homopiperidinyl benzimidazole analogues as fundic relaxants | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-24 | — | — | US | disclosed |
| CN-1411460-A | Substituted homopiperidinyl benzimidazole analogues as fundic relaxants | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-16 | — | — | CN | disclosed |
| CN-1411460-A | Substituted homopiperidinyl benzimidazole analogues as fundic relaxants | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-16 | — | — | CN | disclosed |
| EP-0983263-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998054172-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1998-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | PDE3A, PDE3B, PTGIS | BCHE 2443/4885ACHE 74/4885HTR3A 326/4885 |
| US-20030139393-A1 | Substituted homopiperidinyl benzimidazole analogues as fundic relaxants | HRH2, CBR1, HTR1D | BCHE 3535/4885ACHE 1181/4885HTR3A 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.