Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12969896 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL4079140 | 0.83 | CFTR (0.46) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL6739516 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL22452138 | 0.78 | UTS2R (0.49) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL12960642 | 0.76 | ATM (0.49) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL9502317 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL361852 | 0.75 | CFTR (0.53) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL29672587 | 0.75 | CFTR (0.53) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL22343694 | 0.74 | CFTR (0.48) | SMN1; SMN2CFTRGOPCNPSR1CYP2C9 | |
| SCHEMBL28420767 | 0.74 | NPSR1 (0.37) | SMN1; SMN2NPSR1CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783529-B2 | Pyridazinone compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2017-10-10 | — | — | US | disclosed |
| US-20050104233-A1 | Method of substituent introduction through halogen-metal exchange reaction | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-05-19 | — | — | US | disclosed |
| EP-1510510-A1 | METHOD OF SUBSTITUENT INTRODUCTION THROUGH HALOGEN-METAL EXCHANGE REACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-03-02 | — | — | EP | disclosed |
| EP-0306096-B1 | PROCESS FOR PREPARING DIPHENYL ETHERS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1993-06-09 | — | — | EP | disclosed |
| EP-0310187-B1 | PROCESS FOR PREPARING DIPHENYL ETHERS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1993-06-02 | — | — | EP | disclosed |
| US-5183907-A | Process for preparing diphenyl ethers | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1993-02-02 | — | — | US | disclosed |
| US-4927945-A | Process for preparing diphenyl ethers | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ, B.V. (NL) | 1990-05-22 | — | — | US | disclosed |
| EP-0310187-A2 | Process for preparing diphenyl ethers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1989-04-05 | — | — | EP | disclosed |
| EP-0306096-A1 | Process for preparing diphenyl ethers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1989-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050104233-A1 | Method of substituent introduction through halogen-metal exchange reaction | SLC39A11, SLC30A6, SLC39A3 | SMN1; SMN2 3786/4885CFTR 4132/4885GOPC 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.