Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 10/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CFB | P00751 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948011 | 1.00 | POLB (0.40) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL12891024 | 0.85 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL12156688 | 0.85 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL12891026 | 0.85 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL13212589 | 0.79 | CFB (0.38) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL13500529 | 0.79 | CFB (0.38) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL13212595 | 0.79 | CFB (0.38) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL20569702 | 0.77 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL13656348 | 0.74 | SPHK2 (0.46) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL13656349 | 0.74 | SPHK2 (0.46) | POLBL3MBTL1SPHK2SPHK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126838-A4 | NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2005-02-16 | — | — | EP | disclosed |
| EP-1126838-A1 | NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025776-A1 | NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-05-11 | — | — | WO | disclosed |