Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 10/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CFB | P00751 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428879 | 1.00 | POLB (0.40) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL12891024 | 0.85 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL12156688 | 0.85 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL12891026 | 0.85 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL13212589 | 0.79 | CFB (0.38) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL13500529 | 0.79 | CFB (0.38) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL13212595 | 0.79 | CFB (0.38) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL20569702 | 0.77 | POLB (0.42) | POLBL3MBTL1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL13656348 | 0.74 | SPHK2 (0.46) | POLBL3MBTL1SPHK2SPHK1PARP1 | |
| SCHEMBL13656349 | 0.74 | SPHK2 (0.46) | POLBL3MBTL1SPHK2SPHK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030207919-A1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use | NICOX S.A. (FR) | 2003-11-06 | — | — | US | disclosed |
| US-6593347-B2 | Especially a nitrosated and/or nitrosylated arylpropionic acid, arylacetic acid, enolic anilide or an oxicam | NITROMED, INC. | 2003-07-15 | — | — | US | disclosed |
| US-20020016322-A1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositons and methods of use | NICOX S.A. (FR) | 2002-02-07 | — | — | US | disclosed |
| US-6297260-B1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use | NITROMED, INC. | 2001-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016322-A1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositons and methods of use | NOS2, NOS3, NOS1 | POLB 3012/4885L3MBTL1 4541/4885SPHK2 2031/4885 |
| US-20030207919-A1 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use | NOS2, NOS1, NOS3 | POLB 4189/4885L3MBTL1 4746/4885SPHK2 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.