Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207049 | 1.00 | IGF1R (0.57) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| SCHEMBL11286656 | 1.00 | IGF1R (0.57) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| SCHEMBL93545 | 1.00 | IGF1R (0.57) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| SCHEMBL9422698 | 1.00 | IGF1R (0.57) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| SCHEMBL12827576 | 1.00 | IGF1R (0.57) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| Methyl Alcohol SCHEMBL9951500 | 0.98 | IGF1R (0.55) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| SCHEMBL285785 | 0.98 | IGF1R (0.59) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| SCHEMBL80441 | 0.91 | IGF1R (0.55) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| Toluene SCHEMBL7575476 | 0.90 | IGF1R (0.52) | IGF1RALOX15CA2CYP4A11CYP4F2 | |
| Propylene Glycol SCHEMBL9068204 | 0.89 | IGF1R (0.47) | IGF1RALOX15CA2CYP4A11CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256121-A1 | e.g. 3-(4-fluorophenyl)-N-{5-[2-(methylamino)pyrimidin-4-yl]thien-2-yl}propanamide; PKB/Akt kinase inhibitor; anticarcinogenic agent; carcinoma, cancer metastases, squamous cell carcinoma, esophageal squamous cell carcinoma, oral carcinoma, cutaneous T cell lymphoma, Hodgkin's lymphoma | CHIRON CORPORATION (US) | 2005-11-17 | — | — | US | disclosed |
| EP-0803555-B1 | Top coating compositions | TOYOTA MOTOR CO LTD (JP) | 2002-07-24 | — | — | EP | disclosed |
| EP-0803555-A2 | Top coating compositions | TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) | 1997-10-29 | — | — | EP | disclosed |
| EP-0305060-B1 | Polymer non-aqueous dispersion, process for preparing the same and coating composition formulated therewith | NIPPON OILS & FATS CO LTD (JP) | 1994-07-27 | — | — | EP | disclosed |
| EP-0382454-B1 | High solids coating composition, and coated articles and coating process using the same | NIPPON OILS & FATS CO LTD (JP) | 1994-06-08 | — | — | EP | disclosed |
| EP-0416329-B1 | Resin composition for use as paint | NIPPON OILS & FATS CO LTD (JP) | 1994-06-01 | — | — | EP | disclosed |
| EP-0267731-B1 | HIGH SOLIDS COATING COMPOSITIONS | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-5093390-A | Automobile paints | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1992-03-03 | — | — | US | disclosed |
| US-5091492-A | Copolymer of polcyclic compound contiaing (meth)acryloyloxy group and unsaturated monomer | NIPPON OIL AND FATS CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |
| EP-0416329-A1 | Resin composition for use as paint | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1991-03-13 | — | — | EP | disclosed |
| US-4963601-A | Polymer non-aqueous dispersion, process for preparing the same and coating composition formulated therewith | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1990-10-16 | — | — | US | disclosed |
| EP-0382454-A1 | High solids coating composition, and coated articles and coating process using the same | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1990-08-16 | — | — | EP | disclosed |
| EP-0185338-B1 | PROCESS FOR COATING SUBSTRATES HAVING ELECTRICALLY CONDUCTIVE SURFACES | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1989-05-24 | — | — | EP | disclosed |
| EP-0305060-A2 | Polymer non-aqueous dispersion, process for preparing the same and coating composition formulated therewith | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1989-03-01 | — | — | EP | disclosed |
| EP-0267731-A2 | High solids coating compositions | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1988-05-18 | — | — | EP | disclosed |
| EP-0185338-A1 | Process for coating substrates having electrically conductive surfaces | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1986-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256121-A1 | e.g. 3-(4-fluorophenyl)-N-{5-[2-(methylamino)pyrimidin-4-yl]thien-2-yl}propanamide; PKB/Akt kinase inhibitor; anticarcinogenic agent; carcinoma, cancer metastases, squamous cell carcinoma, esophageal squamous cell carcinoma, oral carcinoma, cutaneous T cell lymphoma, Hodgkin's lymphoma | MALT1, AKT1, PIK3CA | IGF1R 1010/4885ALOX15 3443/4885CA2 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.