Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xylene SCHEMBL6429103 | 0.89 | IGF1R (0.57) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL6207049 | 0.89 | IGF1R (0.57) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL12827576 | 0.89 | IGF1R (0.57) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL11286656 | 0.89 | IGF1R (0.57) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL93545 | 0.89 | IGF1R (0.57) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL9422698 | 0.89 | IGF1R (0.57) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| Methyl Alcohol SCHEMBL9951500 | 0.87 | IGF1R (0.55) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL285785 | 0.87 | IGF1R (0.59) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL80441 | 0.80 | IGF1R (0.55) | IGF1RALOX15CA2CYP4F2CYP4A11 | |
| SCHEMBL28411256 | 0.79 | IGF1R (0.52) | IGF1RALOX15HRH1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460936-B1 | Methanol copolymerization of ethylene | DU PONT (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0460936-A1 | Methanol copolymerization of ethylene | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| US-5028674-A | Methanol copolymerization of ethylene | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-02 | — | — | US | disclosed |