Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340384 | 0.86 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL25594806 | 0.84 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL132349 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL1203937 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL193513 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL23896338 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL8058978 | 0.80 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL20951937 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL359087 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL17439187 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875419-B2 | Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-04-05 | — | — | US | disclosed |
| EP-1390079-A2 | PARAMAGNETIC METAL ION-BASED MACROCYLIC CONTRAST AGENTS | Board of Regents University of Texas System (US) | 2004-02-25 | — | — | EP | disclosed |
| US-20020127182-A1 | Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2002-09-12 | — | — | US | disclosed |
| WO-2002043775-A2 | PARAMAGNETIC METAL ION-BASED MACROCYCLIC CONTRAST AGENTS | GODFREY, Cullen, M. (US) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020127182-A1 | Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use | MTCH2, HRH3, HRH1 | ALDH1A1 3813/4885SMN1; SMN2 4635/4885KDM4E 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.