Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28831335 | 0.98 | PRCP (0.57) | PRCPSLC22A1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL27985631 | 0.95 | PRCP (0.60) | PRCPSLC22A1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL1009943 | 0.89 | PRCP (0.64) | PRCPSLC22A1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL20365826 | 0.88 | PRCP (0.48) | PRCPSLC22A1OPRM1OPRK1SMN1; SMN2 | |
| SCHEMBL6923373 | 0.84 | PRCP (0.40) | PRCPSLC22A1ALDH1A1 | |
| SCHEMBL9480995 | 0.84 | PRCP (0.41) | PRCPSLC22A1OPRM1OPRK1SMN1; SMN2 | |
| SCHEMBL4340398 | 0.83 | PRCP (0.58) | PRCPSLC22A1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL38665128 | 0.83 | CYP2D6 (0.39) | PRCPSLC22A1ALDH1A1 | |
| SCHEMBL29532113 | 0.83 | CYP2D6 (0.39) | PRCPSLC22A1ALDH1A1 | |
| SCHEMBL29768301 | 0.82 | PRCP (0.68) | PRCPSLC22A1OPRM1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586182-A | Preparation method of 1-cyano-2-substituted 1,2,3,4 tetrahydroisoquinoline compound | 遵义医科大学 | 2024-02-23 | — | — | CN | claimed |
| CN-114874139-A | Synthesis method of 1-benzyl or allyl 3, 4-dihydroisoquinoline | 新疆大学 | 2022-08-09 | — | — | CN | claimed |
| CN-106967216-B | A kind of covalent organic framework material and the preparation method and application thereof of imines connection | 吉林大学 | 2019-08-02 | — | — | CN | claimed |
| CN-106967216-A | A kind of covalent organic framework material of imines connection and preparation method and application | 吉林大学 | 2017-07-21 | — | — | CN | claimed |
| CN-113950477-B | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-117603139-A | Preparation method of 1- (hetero) aryl-2- (sulfonyl) -1,2,3,4 tetrahydroisoquinoline compound | 遵义医科大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-117586182-A | Preparation method of 1-cyano-2-substituted 1,2,3,4 tetrahydroisoquinoline compound | 遵义医科大学 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586182-A | Preparation method of 1-cyano-2-substituted 1,2,3,4 tetrahydroisoquinoline compound | 遵义医科大学 | 2024-02-23 | — | — | CN | disclosed |
| CN-116813456-A | Method for synthesizing cyclic carbonyl compounds from benzylidene compounds | 华东理工大学 | 2023-09-29 | — | — | CN | disclosed |
| CN-114957207-A | Application of water-soluble photocatalyst in photocatalytic reaction | 中国人民解放军海军军医大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-109053570-B | Antitumor effect of tetrahydroisoquinoline structure compound | 广东医科大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-113950477-A | Modulators of progranulin and methods of use thereof | 阿库达医疗公司 | 2022-01-18 | — | — | CN | disclosed |
| CN-106967216-A | A kind of covalent organic framework material of imines connection and preparation method and application | 吉林大学 | 2017-07-21 | — | — | CN | disclosed |
| CN-104324754-B | Preparation method and application of bimetallic catalytic photo-functional POM/MOFs | 大连理工大学 | 2017-01-25 | — | — | CN | disclosed |
| CN-103896938-A | Method for preparing solifenacin succinate | Chongqing kerui pharmaceutical group co ltd | 2014-07-02 | — | — | CN | disclosed |
| EP-1521583-A1 | 7,8,9,10-TETRAHYDRO-6H-AZEPINO, 6,7,8,9-TETRAHYDRO-PYRIDO AND 2,3-DIHYDRO-2H-PYRROLO (2,1-B)-QUINAZOLINONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004096774-A1 | ACYL ISOINDOLINE DERIVATIVES AND ACYL ISOQUINOLINE DERIVATIVES AS ANTI-VIRAL AGENTS | GLAXO GROUP LIMITED (GB) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004004733-A1 | 7,8,9,10-TETRAHYDRO-6H-AZEPINO, 6,7,8,9-TETRAHYDRO-PYRIDO AND 2,3-DIHYDRO-2H-PYRROLO[2,1-B]-QUINAZOLINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-01-15 | — | — | WO | disclosed |
| JP-2001026580-A | PRODUCTION OF OPTICALLY ACTIVE 1-ARYL-1,2,3,4- TETRAHYDROQUINOLINE | SUMITOMO CHEM CO LTD | 2001-01-30 | — | — | JP | disclosed |
| US-4001244-A | 1-ARYL-3,4-DIHYDRO-2(1H)-ISOQUINOLINE CARBONYL CHLORIDES | G. D. SEARLE & CO. (US) | 1977-01-04 | — | — | US | disclosed |