SCHEMBL6429798

SCHEMBL6429798

[CH2]c1ccc(NC(=O)/C=C/c2cnn(Cc3ccccc3)c2-c2ccc(F)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 2/20 0.46
MMP2 P08253 2/20 0.46
MMP9 P14780 2/20 0.46
EGFR P00533 1/20 0.46
CCNC P24863 5/20 0.42
CDK8 P49336 5/20 0.42
PTGDR2 Q9Y5Y4 1/20 0.42
CDK19 Q9BWU1 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 2/20 0.41
HDAC2 Q92769 2/20 0.40
PTGER4 P35408 1/20 0.39
KCNJ6 P48051 1/20 0.39
KCNJ5 P48544 1/20 0.39
KCNJ3 P48549 1/20 0.39
RAB9A P51151 6/20 0.38
NPC1 O15118 5/20 0.38
MAPT P10636 2/20 0.38
MAOB P27338 1/20 0.38
ADORA3 P0DMS8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4831264 0.87 EGFR (0.43) MMP1MMP2MMP9EGFRCCNC
SCHEMBL4831275 0.87 EGFR (0.43) MMP1MMP2MMP9EGFRCCNC
SCHEMBL4826898 0.83 CCNC (0.39) MMP1MMP2MMP9EGFRCCNC
SCHEMBL4826902 0.83 PTGDR2 (0.40) MMP1MMP2MMP9EGFRCCNC
SCHEMBL4826913 0.83 CCNC (0.39) MMP1MMP2MMP9EGFRCCNC
SCHEMBL4833619 0.83 GAA (0.49) SMN1; SMN2KDM4EHDAC2PTGER4RAB9A
SCHEMBL4833608 0.83 GAA (0.49) SMN1; SMN2KDM4EHDAC2PTGER4RAB9A
SCHEMBL6429805 0.82 MMP1 (0.44) MMP1MMP2MMP9EGFRCCNC
SCHEMBL6432454 0.81 GAA (0.58) SMN1; SMN2KDM4EHDAC2RAB9AMAPT
SCHEMBL4831386 0.80 EGFR (0.48) MMP1MMP2MMP9EGFRCCNC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1556032-A1 AGENT FOR PREVENTING OR TREATING NEUROPATHY Takeda Pharmaceutical Company Limited (JP) 2005-07-27 EP disclosed
WO-2004039365-A1 AGENT FOR PREVENTING OR TREATING NEUROPATHY TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-05-13 WO disclosed