Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10710425 | 0.82 | CYP3A4 (0.38) | TSHRHSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL10540667 | 0.81 | LMNA (0.50) | TSHRLMNAHPGDHSD17B10ALOX15 | |
| SCHEMBL6555122 | 0.80 | LMNA (0.53) | TSHRLMNAHPGDHSD17B10ALOX15 | |
| SCHEMBL1131580 | 0.78 | HPGD (0.47) | TSHRLMNAHPGDHSD17B10ALOX15 | |
| SCHEMBL1493619 | 0.77 | TSHR (0.53) | TSHRLMNATDP1ALDH1A1MAPT | |
| SCHEMBL5195832 | 0.77 | LMNA (0.58) | TSHRLMNAHPGDHSD17B10ALOX15 | |
| SCHEMBL10435253 | 0.77 | LMNA (0.49) | LMNATDP1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3026390 | 0.74 | LMNA (0.58) | TSHRLMNAHPGDHSD17B10ALOX15 | |
| SCHEMBL28842278 | 0.73 | LMNA (0.53) | TSHRLMNAHPGDHSD17B10ALOX15 | |
| SCHEMBL7613313 | 0.73 | TDP1 (0.49) | TSHRLMNAHPGDHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050037375-A1 | Screening method for ligand-protein interactions | CURAGEN CORPORATION | 2005-02-17 | — | — | US | disclosed |
| EP-1135681-A1 | THREE-HYBRID SCREENING METHOD FOR LIGAND-PROTEIN INTERACTIONS | Curagen Corporation (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000007018-A2 | THREE-HYBRID SCREENING METHOD FOR LIGAND-PROTEIN INTERACTIONS | CURAGEN CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |