Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030121 | 0.88 | HPGD (0.44) | KDM4EGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL6426318 | 0.88 | ALDH1A1 (0.44) | KDM4EGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL5032372 | 0.88 | KDM4E (0.42) | KDM4EGAAHSD17B10ALDH1A1KDR | |
| SCHEMBL6428750 | 0.85 | HPGD (0.46) | KDM4EGAAHSD17B10ALDH1A1KDR | |
| SCHEMBL6426372 | 0.85 | TSHR (0.47) | KDM4EGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL5031151 | 0.85 | ALDH1A1 (0.42) | KDM4EGAAHSD17B10ALDH1A1KDR | |
| SCHEMBL5032418 | 0.85 | KDM4E (0.40) | KDM4EGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL6427572 | 0.84 | RECQL (0.48) | KDM4EGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL5027586 | 0.84 | AURKA (0.40) | KDM4EGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL6425928 | 0.83 | HPGD (0.39) | KDM4EGAAHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | CNKSR1, NR3C2, CSNK2B | KDM4E 2795/4885GAA 4714/4885HSD17B10 2288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.