Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430583 | 0.77 | RXFP1 (0.33) | ALDH1A1RIPK1USP2HTTWEE1 | |
| SCHEMBL5871615 | 0.74 | PDE11A (0.49) | PDE11AALDH1A1HPGDRIPK1HTT | |
| SCHEMBL5872038 | 0.72 | PDE11A (0.66) | PDE11AALDH1A1HPGDHTTWEE1 | |
| SCHEMBL8286065 | 0.69 | PDE11A (0.46) | PDE11AALDH1A1HPGDRIPK1MEN1 | |
| SCHEMBL5871751 | 0.69 | PDE11A (0.48) | PDE11AALDH1A1HPGDHTTATM | |
| SCHEMBL8285210 | 0.67 | PDE11A (0.44) | PDE11AALDH1A1HPGDHTTNOTUM | |
| SCHEMBL8285149 | 0.65 | PDE11A (0.47) | PDE11AALDH1A1HPGDHTTATM | |
| SCHEMBL8362709 | 0.65 | PDE11A (0.39) | PDE11AALDH1A1HPGDRIPK1HTT | |
| SCHEMBL8285196 | 0.65 | PDE11A (0.64) | PDE11AALDH1A1HPGDHTTNOTUM | |
| SCHEMBL6430582 | 0.64 | ACP1 (0.40) | MEN1KMT2AGSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900205-B2 | 1,8-Naphthyridine derivatives and their use to treat diabetes and related disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-05-31 | — | — | US | disclosed |