Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | KIF5B | P33176 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436584 | 0.87 | RET (0.46) | KDRPDGFRBRETSRCKIF5B | |
| SCHEMBL6436595 | 0.85 | EGFR (0.53) | KDRSRCALDH1A1EGFRERBB2 | |
| SCHEMBL6430668 | 0.84 | SRC (0.49) | RETSRCKIF5BEGFRERBB2 | |
| SCHEMBL6436364 | 0.83 | FLT1 (0.50) | KDRPDGFRBRETKIF5BFGFR1 | |
| Hydrochloric Acid SCHEMBL6434957 | 0.80 | RET (0.58) | KDRRETSRCKIF5BEGFR | |
| SCHEMBL6431249 | 0.80 | RET (0.60) | KDRRETSRCKIF5BEGFR | |
| SCHEMBL6431137 | 0.80 | EHMT2 (0.45) | KDRPDGFRBRETKIF5BKDM4E | |
| SCHEMBL6431459 | 0.79 | RET (0.54) | KDRRETSRCKIF5BEGFR | |
| SCHEMBL6436105 | 0.77 | MAP2K1 (0.48) | KDRSRCEGFRERBB2 | |
| SCHEMBL6436287 | 0.75 | RET (0.54) | KDRRETSRCKIF5BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |