Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.53 |
| ▸ | FLT1 | P17948 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431414 | 0.86 | KDR (0.60) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6430673 | 0.85 | KDR (0.44) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6431782 | 0.84 | SRC (0.60) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6432228 | 0.82 | FLT1 (0.61) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6430831 | 0.78 | EGFR (0.78) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6431410 | 0.78 | EGFR (0.78) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6435236 | 0.78 | FGFR1 (0.57) | EGFRFGFR1FLT1KDRFLT4 | |
| Hydrochloric Acid SCHEMBL6882131 | 0.78 | EGFR (0.77) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6383464 | 0.77 | SRC (0.64) | EGFRFGFR1FLT1KDRFLT4 | |
| SCHEMBL6380759 | 0.75 | SRC (0.64) | EGFRFGFR1FLT1KDRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |