Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455925 | 0.84 | ENPP1 (0.65) | KDRFGFR1FLT1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6432715 | 0.81 | FGFR1 (0.64) | KDRFGFR1FLT1KDM4EALDH1A1 | |
| SCHEMBL6431753 | 0.80 | FLT1 (0.78) | KDRFGFR1FLT1EGFRSRC | |
| Hydrochloric Acid SCHEMBL6438819 | 0.79 | FLT1 (0.77) | KDRFGFR1FLT1EGFRSRC | |
| SCHEMBL2746706 | 0.79 | EHMT2 (0.67) | KDRFGFR1FLT1EGFREHMT2 | |
| SCHEMBL2746476 | 0.79 | EHMT2 (0.50) | KDRFGFR1FLT1EGFREHMT2 | |
| SCHEMBL22441436 | 0.79 | KDR (0.60) | KDRFGFR1FLT1EGFREHMT2 | |
| SCHEMBL29354537 | 0.79 | KDR (0.60) | KDRFGFR1FLT1EGFREHMT2 | |
| SCHEMBL5201839 | 0.79 | KDR (0.60) | KDRFGFR1FLT1EGFREHMT2 | |
| SCHEMBL29387468 | 0.78 | SRC (0.60) | EGFRCGASSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |