Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 8/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 8/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492035 | 0.89 | AVPR1B (0.46) | AVPR1BAVPR1ABDKRB1MEN1KMT2A | |
| SCHEMBL645571 | 0.86 | AVPR1B (0.46) | AVPR1BAVPR1AMEN1KMT2A | |
| SCHEMBL642950 | 0.85 | AVPR1B (0.45) | AVPR1BAVPR1AMEN1KMT2A | |
| SCHEMBL493144 | 0.77 | BDKRB1 (0.40) | AVPR1BAVPR1ABDKRB1 | |
| SCHEMBL643968 | 0.77 | AVPR1B (0.43) | AVPR1BAVPR1ABDKRB1HTR6 | |
| SCHEMBL492675 | 0.77 | BDKRB1 (0.41) | AVPR1BAVPR1ABDKRB1 | |
| SCHEMBL493601 | 0.73 | AVPR1B (0.37) | AVPR1BAVPR1ABDKRB1HTR6 | |
| SCHEMBL493207 | 0.71 | BDKRB1 (0.42) | AVPR1ABDKRB1 | |
| SCHEMBL492944 | 0.71 | BDKRB1 (0.42) | AVPR1ABDKRB1 | |
| SCHEMBL493671 | 0.71 | BDKRB1 (0.41) | AVPR1BBDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119633-B2 | N-{2-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-ethyl}-N-ethyl-4-methoxy-2,3,6-trimethyl-phenylsulfonamide; condensing the N-carboxyalkyl phenylsulfonamide with the substituted piperidine; bradykinin receptor antagonists; analgesics; antidiabetics; angiogenesis inhibitors; rheumatic diseases | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |