SCHEMBL6431007

SCHEMBL6431007

COc1cc2c(Nc3cc(O)c(Cl)cc3F)ccnc2cc1OCCCc1cccnc1

nearest known ligand 0.72

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 9/20 0.72
FGFR1 P11362 5/20 0.72
KDR P35968 10/20 0.57
FLT4 P35916 2/20 0.53
FGFR2 P21802 1/20 0.53
FGFR4 P22455 1/20 0.53
FGFR3 P22607 1/20 0.53
RET P07949 2/20 0.47
KIF5B P33176 1/20 0.47
SRC P12931 3/20 0.46
EGFR P00533 6/20 0.46
EPHA2 P29317 1/20 0.44
EPHB4 P54760 1/20 0.44
ABL1 P00519 2/20 0.43
SYK P43405 1/20 0.43
RAF1 P04049 1/20 0.41
BRAF P15056 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6431015 0.85 FLT1 (0.51) FLT1FGFR1KDRFLT4FGFR2
SCHEMBL6432152 0.84 FLT1 (1.00) FLT1FGFR1KDRFLT4FGFR2
SCHEMBL6437903 0.84 FLT1 (0.84) FLT1FGFR1KDRFLT4FGFR2
SCHEMBL6430998 0.84 FLT1 (0.75) FLT1FGFR1KDRFLT4FGFR2
Hydrochloric Acid SCHEMBL6431098 0.83 FLT1 (0.98) FLT1FGFR1KDRFLT4FGFR2
Hydrochloric Acid SCHEMBL6435465 0.83 FLT1 (0.83) FLT1FGFR1KDRFLT4FGFR2
Hydrochloric Acid SCHEMBL6431427 0.83 FLT1 (0.74) FLT1FGFR1KDRFLT4FGFR2
SCHEMBL6436401 0.82 FLT1 (0.82) FLT1FGFR1KDRFLT4FGFR2
SCHEMBL6433880 0.82 FLT1 (0.75) FLT1FGFR1KDRFLT4FGFR2
Hydrochloric Acid SCHEMBL6431121 0.81 FLT1 (0.80) FLT1FGFR1KDRFLT4FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929526-B1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ASTRAZENECA AB (SE) 2005-07-27 EP claimed
US-6809097-B1 ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY ZENECA LIMITED (GB) 2004-10-26 US claimed
EP-0929526-A1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ZENECA LIMITED (GB) 1999-07-21 EP claimed
WO-1998013350-A1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ZENECA LIMITED (GB) 1998-04-02 WO claimed
EP-0929526-B1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ASTRAZENECA AB (SE) 2005-07-27 EP disclosed
US-6809097-B1 ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY ZENECA LIMITED (GB) 2004-10-26 US disclosed
EP-0929526-A1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ZENECA LIMITED (GB) 1999-07-21 EP disclosed
WO-1998013350-A1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ZENECA LIMITED (GB) 1998-04-02 WO disclosed