Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 10/20 | 0.41 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894661 | 0.71 | MEN1 (0.64) | MEN1KMT2AMAPK9MAPK10CCKBR | |
| SCHEMBL8103882 | 0.70 | FYN (0.42) | MEN1KMT2ADRD3DRD2DRD4 | |
| SCHEMBL3479821 | 0.70 | MAPK9 (0.54) | MEN1KMT2AMAPK9MAPK10DRD3 | |
| SCHEMBL3480051 | 0.70 | MAPK9 (0.54) | MEN1KMT2AMAPK9MAPK10DRD3 | |
| SCHEMBL4967650 | 0.70 | MAPK9 (0.53) | MEN1KMT2AMAPK9MAPK10DRD3 | |
| SCHEMBL3480006 | 0.69 | MAPK9 (0.55) | MEN1KMT2AMAPK9MAPK10DRD3 | |
| SCHEMBL8108257 | 0.69 | DRD3 (0.48) | DRD3DRD2 | |
| SCHEMBL3479709 | 0.69 | MAPK9 (0.54) | MEN1KMT2AMAPK9MAPK10DRD3 | |
| SCHEMBL6439275 | 0.69 | MEN1 (0.63) | MEN1KMT2AMAPK9MAPK10CCKBR | |
| SCHEMBL13881587 | 0.69 | MEN1 (0.54) | MEN1KMT2ACCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218374-B1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2005-11-16 | — | — | EP | claimed |
| EP-1218374-B1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2005-11-16 | — | — | EP | disclosed |
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |