Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009166 | 0.84 | KDR (0.37) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL2114117 | 0.80 | KDR (0.46) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL2114116 | 0.80 | LRRK2 (0.42) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL2116248 | 0.78 | KDR (0.40) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL2116213 | 0.77 | FGFR1 (0.51) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL722802 | 0.76 | ALK (0.52) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL2116963 | 0.76 | PDGFRB (0.46) | KDRKITPDGFRBFGFR1EGFR | |
| SCHEMBL2114389 | 0.75 | FLT3 (0.41) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL6324208 | 0.73 | FLT3 (0.60) | KDRFLT3KITFLT4PDGFRB | |
| SCHEMBL6324202 | 0.73 | FLT3 (0.60) | KDRFLT3KITFLT4PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |