Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431038 | 0.84 | KDR (0.36) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL2116213 | 0.81 | FGFR1 (0.51) | KDRFGFR1PDGFRBEGFRPDPK1 | |
| SCHEMBL6319851 | 0.75 | KDR (0.56) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL6319847 | 0.75 | KDR (0.56) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL7200213 | 0.73 | FGFR1 (0.44) | KDRFGFR1PDGFRBEGFRPDPK1 | |
| SCHEMBL6321926 | 0.71 | KDR (0.56) | KDRFGFR1PDGFRBEGFRPDPK1 | |
| SCHEMBL6762725 | 0.71 | KDR (0.56) | KDRFGFR1PDGFRBEGFRPDPK1 | |
| SCHEMBL2118752 | 0.71 | KDR (0.46) | KDRFGFR1PDGFRBEGFRRET | |
| SCHEMBL2114116 | 0.71 | LRRK2 (0.42) | KDRFGFR1PDGFRBEGFRPDPK1 | |
| SCHEMBL2114117 | 0.71 | KDR (0.46) | KDRFGFR1PDGFRBEGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |