Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 4/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 4/20 | 0.44 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432661 | 0.88 | FLT1 (0.55) | FLT1FGFR1SRCKDRMAPK14 | |
| SCHEMBL7452247 | 0.87 | MAPK14 (0.58) | FLT1FGFR1SRCRAF1BRAF | |
| SCHEMBL6431182 | 0.86 | EGFR (0.54) | FLT1FGFR1SRCKDRMAPK14 | |
| SCHEMBL6434966 | 0.84 | FLT1 (0.51) | FLT1FGFR1SRCKDRMAPK14 | |
| SCHEMBL6432013 | 0.82 | FLT1 (0.49) | FLT1FGFR1SRCKDRMAPK14 | |
| SCHEMBL8711202 | 0.82 | RAF1 (0.37) | FLT1FGFR1SRCRAF1BRAF | |
| SCHEMBL6432009 | 0.81 | SRC (0.45) | FLT1FGFR1SRCKDRMAPK14 | |
| SCHEMBL6431462 | 0.81 | FLT1 (0.51) | FLT1FGFR1SRCRAF1BRAF | |
| SCHEMBL6431016 | 0.80 | EGFR (0.53) | FLT1FGFR1SRCBRAFKDR | |
| Hydrochloric Acid SCHEMBL6435465 | 0.78 | FLT1 (0.83) | FLT1FGFR1SRCRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |