Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509887 | 0.84 | SRC (0.43) | SRCFGFR1FLT1KDREGFR | |
| Hydrochloric Acid SCHEMBL6434139 | 0.84 | FLT1 (0.63) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6432661 | 0.83 | FLT1 (0.55) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6432187 | 0.83 | FLT1 (0.64) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6431182 | 0.82 | EGFR (0.54) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6431467 | 0.81 | FLT1 (0.54) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6434966 | 0.80 | FLT1 (0.51) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6432013 | 0.77 | FLT1 (0.49) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL6431016 | 0.76 | EGFR (0.53) | SRCFGFR1FLT1KDREGFR | |
| SCHEMBL7451653 | 0.71 | EGFR (0.59) | SRCFGFR1FLT1KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |