SCHEMBL6432037

SCHEMBL6432037

CC(C)(C)NC(=O)C1CC[C@H]2[C@@H]3CC=C4NC(=O)CC[C@]4(C)[C@@H]3CC[C@]12C

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 12/20 0.66
SRD5A1 P18405 8/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6545719 1.00 SRD5A2 (0.66) SRD5A2SRD5A1
SCHEMBL9116882 0.89 SRD5A1 (0.56) SRD5A2SRD5A1
SCHEMBL9022346 0.88 SRD5A2 (0.60) SRD5A2SRD5A1
SCHEMBL9022210 0.88 SRD5A2 (0.60) SRD5A2SRD5A1
SCHEMBL9022217 0.88 SRD5A2 (0.60) SRD5A2SRD5A1
SCHEMBL9022357 0.88 SRD5A2 (0.60) SRD5A2SRD5A1
SCHEMBL9068013 0.87 SRD5A1 (0.53) SRD5A2SRD5A1
SCHEMBL27814934 0.87 SRD5A2 (0.62) SRD5A2SRD5A1
SCHEMBL14185033 0.85 SRD5A1 (0.58) SRD5A2SRD5A1
SCHEMBL12423999 0.85 SRD5A1 (0.58) SRD5A2SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994011387-A2 A PROCESS FOR THE PRODUCTION OF FINASTERIDE MERCK & CO., INC. (US) 1994-05-26 WO claimed
EP-1496909-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER AstraZeneca AB (SE) 2005-01-19 EP disclosed
EP-1116725-B1 PROCESS FOR OBTAINING 17BETA-(N-TERC-BUTYLCARBAMOYL)-3-ONE-4-AZA-STEROIDS RAGACTIVES SL (ES) 2004-01-14 EP disclosed
WO-2003088971-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2003-10-30 WO disclosed
WO-2003027132-A2 METHOD OF PREPARING 17β-(N-TERT-BUTYLCARBAMOYL)-3-ONE STEROID DERIVATIVES HANMI PHARM. CO., LTD. (KR) 2003-04-03 WO disclosed
US-6509466-B2 Reacting 17 beta-(alkoxycarbonyl)-3-one-4-aza-steroid with lithium tert-butylamide in an organic solvent RAGA CONSULTORES, S.L. (ES) 2003-01-21 US disclosed
US-20010008895-A1 Process for obtaining 17 beta-(N-tert-butylcarbamoyl)-3-one4-aza-steroids RAGA CONSULTORES, S.L. 2001-07-19 US disclosed
EP-1116725-A1 PROCESS FOR OBTAINING 17BETA-(N-TERC-BUTYLCARBAMOYL)-3-ONE-4-AZA-STEROIDS Raga Consultores, S.L. (ES) 2001-07-18 EP disclosed
EP-0542802-A1 STIMULATION OF HAIR GROWTH WITH POTASSIUM CHANNEL OPENERS AND 5-g(a)-REDUCTASE INHIBITORS. UPJOHN CO (US) 1993-05-26 EP disclosed
WO-1992002225-A1 STIMULATION OF HAIR GROWTH WITH POTASSIUM CHANNEL OPENERS AND 5α-REDUCTASE INHIBITORS THE UPJOHN COMPANY (US) 1992-02-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010008895-A1 Process for obtaining 17 beta-(N-tert-butylcarbamoyl)-3-one4-aza-steroids CYP17A1, HSD17B7, CYP51A1 SRD5A2 14/4885SRD5A1 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.