Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.68 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.68 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.64 |
| ▸ | ITGB8 | P26012 | 6/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.64 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.64 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.64 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432178 | 1.00 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432194 | 1.00 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL19465189 | 0.88 | ITGAV (0.72) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL22223379 | 0.87 | ITGAV (0.71) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432333 | 0.84 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432177 | 0.84 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL6432181 | 0.84 | ITGAV (0.68) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL18626284 | 0.81 | ITGAV (0.63) | ITGAVITGB3ITGB6ITGB8ITGA2B | |
| SCHEMBL7945682 | 0.81 | ITGB3 (0.65) | ITGAVITGB3ITGB6ITGA2BITGB1 | |
| SCHEMBL7945684 | 0.81 | ITGB3 (0.65) | ITGAVITGB3ITGB6ITGA2BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040111-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1040111-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-10-04 | — | — | EP | claimed |
| WO-1999031099-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | claimed |
| EP-1040111-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-06-22 | — | — | EP | disclosed |
| US-6017926-A | Integrin receptor antagonists | MERCK & CO., INC. (US) | 2000-01-25 | — | — | US | disclosed |