Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 20/20 | 0.78 |
| ▸ | ABCC8 | Q09428 | 20/20 | 0.78 |
| ▸ | KCNJ11 | Q14654 | 20/20 | 0.78 |
| ▸ | KCNJ8 | Q15842 | 20/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435719 | 0.85 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6432145 | 0.75 | ABCC9 (0.76) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL4261099 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6432273 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL4261095 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7235955 | 0.75 | ABCC9 (0.84) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7233437 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL4261651 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7241551 | 0.75 | ABCC9 (0.84) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL5075549 | 0.74 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | claimed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | claimed |
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1175382-B1 | METHOD FOR THE DIHYDROXYLATION OF OLEFINS USING TRANSITION-METAL CATALYSTS | BAYER CHEMICALS AG (DE) | 2005-02-09 | — | — | EP | disclosed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| EP-1175382-A1 | METHOD FOR THE DIHYDROXYLATION OF OLEFINS USING TRANSITION-METAL CATALYSTS | Bayer Aktiengesellschaft (DE) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000064848-A1 | METHOD FOR THE DIHYDROXYLATION OF OLEFINS USING TRANSITION-METAL CATALYSTS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-11-02 | — | — | WO | disclosed |