Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897002 | 0.86 | GAA (0.56) | ALDH1A1MAPTKDM4ERAB9AHPGD | |
| SCHEMBL21056853 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL6437170 | 0.81 | MAPT (0.56) | SMN1; SMN2ALDH1A1MAPTRAB9AHPGD | |
| SCHEMBL6439412 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL1841640 | 0.75 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL29790003 | 0.75 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL27502587 | 0.75 | MKNK1 (0.42) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL6434460 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5779631 | 0.74 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL31083364 | 0.73 | FNTA (0.55) | SMN1; SMN2ALDH1A1MAPTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| CN-1214008-C | Therapeutic biaryl derivatives | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | CN | disclosed |
| CN-1312800-A | Therapeutic biaryl derivatives | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | CN | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |