Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 19/20 | 0.55 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.47 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433042 | 1.00 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6304539 | 0.95 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6304533 | 0.95 | ITGAV (0.57) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6435940 | 0.85 | ITGAV (0.53) | ITGAVITGB3ITGB6ITGB1ITGA2B | |
| SCHEMBL6435942 | 0.85 | ITGAV (0.53) | ITGAVITGB3ITGB6ITGB1ITGA2B | |
| SCHEMBL6303755 | 0.85 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6303762 | 0.85 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGB1ITGA5 | |
| SCHEMBL6222793 | 0.80 | ITGAV (0.49) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL6433481 | 0.79 | ITGAV (0.49) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL7587385 | 0.79 | ITGAV (0.40) | ITGAVITGB3ITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040111-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-06-22 | — | — | EP | disclosed |
| US-6017926-A | Integrin receptor antagonists | MERCK & CO., INC. (US) | 2000-01-25 | — | — | US | disclosed |