Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 17/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 16/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 15/20 | 0.48 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.30 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.30 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433079 | 1.00 | ADRB3 (0.48) | ADRB3ADRB1ADRB2RORBSLC16A3 | |
| SCHEMBL6432600 | 0.90 | ADRB1 (0.45) | ADRB3ADRB1ADRB2 | |
| SCHEMBL6432603 | 0.90 | ADRB1 (0.45) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7977640 | 0.87 | ADRB1 (0.49) | ADRB3ADRB1ADRB2 | |
| SCHEMBL6435349 | 0.87 | ADRB1 (0.44) | ADRB3ADRB1ADRB2 | |
| SCHEMBL6435351 | 0.87 | ADRB1 (0.44) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7977641 | 0.87 | ADRB1 (0.49) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7964109 | 0.87 | ADRB1 (0.44) | ADRB3ADRB1ADRB2 | |
| SCHEMBL7964112 | 0.87 | ADRB1 (0.44) | ADRB3ADRB1ADRB2 | |
| SCHEMBL6432983 | 0.86 | ADRB1 (0.43) | ADRB3ADRB1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |