Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728113 | 0.84 | KMO (1.00) | KMO | |
| SCHEMBL3675550 | 0.84 | KMO (0.66) | KMOMEN1KMT2A | |
| SCHEMBL7406071 | 0.84 | KMO (0.66) | KMOMEN1KMT2A | |
| SCHEMBL728409 | 0.84 | KMO (0.66) | KMOMEN1KMT2A | |
| SCHEMBL4386002 | 0.84 | KMO (1.00) | KMO | |
| SCHEMBL3670421 | 0.84 | KMO (1.00) | KMO | |
| SCHEMBL7396571 | 0.81 | KMT2A (0.62) | MEN1KMT2A | |
| SCHEMBL727064 | 0.80 | TSHR (0.59) | KMOKMT2A | |
| SCHEMBL6433509 | 0.78 | KMO (0.81) | KMO | |
| SCHEMBL27740943 | 0.73 | NR4A2 (0.65) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581216-A1 | KYNURENINE 3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES BY INCREASING THE NUMBER OF ISLETS OF LANGERHANS CELLS | MERCK PATENT GmbH (DE) | 2005-10-05 | — | — | EP | claimed |
| WO-2004060368-A1 | KYNURENINE 3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES BY INCREASING THE NUMBER OF ISLETS OF LANGERHANS CELLS | MERCK PATENT GMBH (DE) | 2004-07-22 | — | — | WO | claimed |