Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.67 |
| ▸ | IGF1R | P08069 | 18/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 17/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.67 |
| ▸ | ERBB3 | P21860 | 16/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826602 | 0.91 | EGFR (0.65) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Ammonia Solution, Strong SCHEMBL4828005 | 0.89 | EGFR (0.53) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6430288 | 0.85 | EGFR (0.76) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4819199 | 0.85 | EGFR (0.76) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL6433960 | 0.84 | EGFR (0.82) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4827462 | 0.84 | EGFR (0.82) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| Acetic Acid SCHEMBL4821510 | 0.82 | EGFR (0.71) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4818816 | 0.82 | EGFR (0.74) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4823834 | 0.82 | EGFR (0.74) | EGFRIGF1RERBB4ERBB2ERBB3 | |
| SCHEMBL4823759 | 0.81 | EGFR (0.80) | EGFRIGF1RERBB4ERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | EGFR 2229/4885IGF1R 2189/4885ERBB4 1025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.