Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 14/20 | 0.83 |
| ▸ | KDR | P35968 | 13/20 | 0.83 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.83 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | FLT4 | P35916 | 6/20 | 0.61 |
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431606 | 0.95 | FLT1 (0.81) | FLT1KDRFGFR1SRCFLT4 | |
| SCHEMBL6431198 | 0.91 | FLT1 (1.00) | FLT1KDRFGFR1SRCFLT4 | |
| Hydrochloric Acid SCHEMBL6431524 | 0.90 | FLT1 (0.98) | FLT1KDRFGFR1SRCFLT4 | |
| Hydrochloric Acid SCHEMBL6434964 | 0.89 | FLT1 (0.82) | FLT1KDRFGFR1SRCFLT4 | |
| Hydrochloric Acid SCHEMBL6436544 | 0.87 | FLT1 (0.79) | FLT1KDRFGFR1SRCFLT4 | |
| SCHEMBL6430988 | 0.87 | FLT1 (0.79) | FLT1KDRFGFR1SRCFLT4 | |
| SCHEMBL7867708 | 0.85 | FLT1 (0.83) | FLT1KDRFGFR1FLT4EGFR | |
| SCHEMBL27530372 | 0.84 | KDR (0.66) | FLT1KDRFGFR1SRCFLT4 | |
| Trifluoroacetic Acid SCHEMBL1889530 | 0.84 | FLT1 (0.71) | FLT1KDRFGFR1SRCFLT4 | |
| SCHEMBL6998899 | 0.84 | FLT1 (0.74) | FLT1KDRFGFR1SRCFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | claimed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | claimed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | claimed |
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |