Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | PIM1 | P11309 | 4/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811949 | 0.85 | KDM4E (0.56) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL10810922 | 0.80 | KDM4E (0.57) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL10810643 | 0.78 | KDM4E (0.61) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL6437384 | 0.76 | JAK2 (0.46) | PDE3BPDE3AKDM4EALDH1A1PARP1 | |
| SCHEMBL10809624 | 0.75 | PDE3B (0.60) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL10812608 | 0.75 | PDE3B (0.60) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL27451450 | 0.73 | PDE3B (0.40) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| SCHEMBL11230846 | 0.70 | PDE3B (0.59) | PDE3BPDE3AKDM4ETSHRMAPT | |
| SCHEMBL6432848 | 0.69 | PDE3A (0.55) | PDE3BPDE3AKDM4EALDH1A1TSHR | |
| Medorinone SCHEMBL121782 | 0.68 | PDE3B (1.00) | PDE3BPDE3AKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010699-B1 | 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | DAINIPPON PHARMACEUTICAL CO (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-6277993-B1 | USEFUL AS A BENZODIAZEPINE INVERSE AGONIST, FOR EXAMPLE, AS PSYCHOANALEPTIC DRUG OR DRUG FOR TREATMENT OF DYSMNESIA IN SENILE DEMENTIA OR ALZHEIMER'S DISEASE | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-08-21 | — | — | US | disclosed |
| US-6172079-B1 | BENZODIAZEPINE INVERSE AGONISTS; ALZHEIMER*S DISEASE; ANXIOLYTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS, ANTIEPILEPTIC AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-1010699-A1 | 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2000-06-21 | — | — | EP | disclosed |