Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811949 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL10810922 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL6434982 | 0.78 | PDE3B (0.50) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL10809624 | 0.75 | PDE3B (0.60) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL10812608 | 0.75 | PDE3B (0.60) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL4394655 | 0.69 | PDE3B (0.51) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL6432848 | 0.69 | PDE3A (0.55) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL13175943 | 0.69 | DYRK1A (0.51) | KDM4EALDH1A1SMN1; SMN2TSHRGAA | |
| Medorinone SCHEMBL121782 | 0.68 | PDE3B (1.00) | KDM4EALDH1A1TSHRKMT2APDE3B | |
| SCHEMBL1352172 | 0.68 | MEN1 (0.55) | KDM4EALDH1A1SMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101952-B1 | 5-ALKYL-1,6-NAPHTHYRIDIN-2(1H)-ONES, INTERMEDIATES, THEIR PREPARATION AND THEIR CARDIOTONIC USE | STERLING DRUG INC. (US) | 1987-09-23 | — | — | EP | disclosed |
| US-4559347-A | 3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic use and preparation thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4517190-A | 5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-14 | — | — | US | disclosed |
| EP-0101952-A1 | 5-Alkyl-1,6-naphthyridin-2(1H)-ones, intermediates, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4415580-A | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same | STERLING DRUG INC. (US) | 1983-11-15 | — | — | US | disclosed |