Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052324 | 0.81 | HDAC1 (0.61) | XDHRAB9AAURKAHDAC1HDAC2 | |
| SCHEMBL5192969 | 0.81 | HDAC1 (0.61) | XDHRAB9AAURKAHDAC1HDAC2 | |
| SCHEMBL5193809 | 0.72 | XDH (0.61) | XDHGSK3BDEGS1RAB9AAURKA | |
| SCHEMBL7052321 | 0.72 | XDH (0.61) | XDHGSK3BDEGS1RAB9AAURKA | |
| SCHEMBL2623138 | 0.70 | XDH (0.62) | XDHGSK3BDEGS1RAB9AAURKA | |
| SCHEMBL6422127 | 0.69 | BRD4 (0.65) | RAB9AAURKABRD4NPC1 | |
| SCHEMBL27570011 | 0.68 | HDAC1 (0.58) | DEGS1RAB9AAURKAHDAC1HDAC2 | |
| SCHEMBL27741454 | 0.67 | DEGS1 (0.50) | XDHDEGS1RAB9ANPC1GLA | |
| SCHEMBL14655898 | 0.67 | SPHK2 (0.49) | XDHDEGS1RAB9ANPC1MAPK1 | |
| SCHEMBL10578168 | 0.66 | XDH (0.50) | XDHDEGS1RAB9ANPC1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1589028-A2 | Modified oligonucleotides, their preparation and their use | Aventis Pharma Deutschland GmbH (DE) | 2005-10-26 | — | — | EP | disclosed |
| EP-0680969-B1 | Modified oligonucleotides, their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2005-07-27 | — | — | EP | disclosed |
| US-6066720-A | WITH AT LEAST ONE 8-AZAPURINE BASE; FORMS MORE STABLE HYBRIDIZATION COMPLEXES WITH NUCLEIC ACIDS; FOR ANTISENSE AGENTS, DIAGNOSTIC AGENTS, PROBES, PRIMERS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-23 | — | — | US | disclosed |
| EP-0680969-A2 | Modified oligonucleotides, their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |