Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.35 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | DRD4 | P21917 | 4/20 | 0.32 |
| ▸ | DRD3 | P35462 | 4/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438655 | 0.92 | CHRM1 (0.35) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6437869 | 0.86 | CHRM1 (0.47) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6437575 | 0.84 | CHRM1 (0.48) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4096132 | 0.82 | CHRM1 (0.39) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4096130 | 0.82 | CHRM1 (0.39) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4097824 | 0.81 | CHRM1 (0.47) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4097825 | 0.81 | CHRM1 (0.47) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4090302 | 0.80 | CHRM1 (0.45) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4090300 | 0.80 | CHRM1 (0.45) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4096528 | 0.80 | CHRM1 (0.49) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461318-B9 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-12-28 | — | — | EP | claimed |
| EP-1461318-B1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-09-14 | — | — | EP | claimed |