Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 16/20 | 0.48 |
| ▸ | DRD2 | P14416 | 10/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 9/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.45 |
| ▸ | DRD4 | P21917 | 8/20 | 0.45 |
| ▸ | DRD3 | P35462 | 8/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437379 | 0.92 | CHRM1 (0.50) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6434431 | 0.87 | CHRM1 (0.51) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6439575 | 0.86 | CHRM1 (0.65) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6436346 | 0.85 | CHRM1 (0.63) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL6435536 | 0.84 | CHRM1 (0.35) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL4101918 | 0.81 | CHRM1 (0.55) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL4091266 | 0.80 | CHRM1 (0.65) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL4096734 | 0.80 | CHRM1 (0.63) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL4095889 | 0.79 | CHRM1 (0.71) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL4101995 | 0.79 | CHRM1 (0.53) | CHRM1DRD2CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461318-B9 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-12-28 | — | — | EP | claimed |
| EP-1461318-B1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-09-14 | — | — | EP | claimed |