Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.57 |
| ▸ | LCK | P06239 | 5/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.52 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | FGR | P09769 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CSK | P41240 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | BLK | P51451 | 1/20 | 0.48 |
| ▸ | BMX | P51813 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431771 | 0.91 | BTK (0.58) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5804464 | 0.86 | BTK (0.60) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5800505 | 0.84 | SRC (0.63) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6435580 | 0.83 | BTK (0.58) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6430702 | 0.81 | BTK (0.76) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL24827957 | 0.79 | BTK (0.71) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL31070358 | 0.78 | SRC (0.58) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL4860031 | 0.78 | BTK (0.56) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6431415 | 0.78 | SRC (0.58) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL25068862 | 0.78 | NUDT14 (0.68) | BTKLCKLYNNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |