Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.66 |
| ▸ | KMO | O15229 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966304 | 0.88 | KDM1A (0.66) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL2762413 | 0.87 | KDM1A (0.68) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL728110 | 0.85 | KDM1A (0.74) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL3673316 | 0.85 | KDM1A (0.80) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL2762558 | 0.84 | MEN1 (0.77) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL2762510 | 0.82 | KDM1A (0.69) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL27182617 | 0.81 | KDM1A (0.68) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL8119102 | 0.81 | KDM1A (0.58) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL8355083 | 0.81 | KDM1A (0.84) | KDM1AKMOMAOAMEN1KMT2A | |
| SCHEMBL727088 | 0.81 | KDM1A (0.74) | KDM1AKMOMAOAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581216-A1 | KYNURENINE 3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES BY INCREASING THE NUMBER OF ISLETS OF LANGERHANS CELLS | MERCK PATENT GmbH (DE) | 2005-10-05 | — | — | EP | claimed |
| WO-2004060368-A1 | KYNURENINE 3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES BY INCREASING THE NUMBER OF ISLETS OF LANGERHANS CELLS | MERCK PATENT GMBH (DE) | 2004-07-22 | — | — | WO | claimed |