Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31466810 | 0.94 | ERN1 (0.41) | ERN1PRKDCPTPN1LMNACYP2A6 | |
| SCHEMBL30952047 | 0.83 | ERN1 (0.35) | ERN1PRKDCLMNA | |
| SCHEMBL29655114 | 0.80 | ERN1 (0.43) | ERN1PRKDCPTPN1LMNA | |
| SCHEMBL933374 | 0.80 | ERN1 (0.43) | ERN1PRKDCPTPN1LMNA | |
| SCHEMBL633623 | 0.78 | ERN1 (0.45) | ERN1PRKDCPTPN1LMNA | |
| SCHEMBL28880933 | 0.77 | PRKDC (0.44) | ERN1PRKDCLMNA | |
| SCHEMBL24485242 | 0.75 | TDP1 (0.42) | ERN1PRKDCPTPN1LMNA | |
| SCHEMBL874654 | 0.75 | ERN1 (0.48) | ERN1 | |
| SCHEMBL29712897 | 0.75 | TDP1 (0.42) | ERN1PRKDCPTPN1LMNA | |
| SCHEMBL31477129 | 0.75 | GRIA1 (0.41) | ERN1PRKDCPTPN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | disclosed |
| US-6593335-B1 | Disease than can be ameliorated with a potassium channel opener in a host mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of the compound of claim 1; said disease is epilepsy, Raynaud's | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | disclosed |