Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432573 | 0.86 | MAPT (0.65) | SLC6A4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11154270 | 0.85 | MAPT (0.51) | SLC6A4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8755657 | 0.85 | SLC6A4 (0.50) | SLC6A4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11160830 | 0.83 | SMN1; SMN2 (0.59) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL27993654 | 0.82 | TSHR (0.53) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2661468 | 0.81 | MEN1 (0.53) | SLC6A4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11021202 | 0.80 | SLC6A4 (0.55) | SLC6A4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL859899 | 0.79 | HSD17B14 (0.57) | MAPTSMN1; SMN2RAB9ANPC1RECQL | |
| SCHEMBL29441715 | 0.79 | MEN1 (0.65) | SLC6A4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2878741 | 0.79 | MEN1 (0.65) | SLC6A4ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| CN-1214008-C | Therapeutic biaryl derivatives | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | CN | disclosed |
| CN-1312800-A | Therapeutic biaryl derivatives | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | CN | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| WO-2001042217-A1 | BETA-3 ADRENOCEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2001-06-14 | — | — | WO | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |