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Sugi Predict / Targets / HSD17B14

HSD17B14

17-beta-hydroxysteroid dehydrogenase 14 · Q9BPX1 · HSD17B14 on Sugi Atlas →

3,618 patent compounds predicted against HSD17B14, 2,112 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL6982962 SCHEMBL6982962 0.45 10/20
SCHEMBL319346 SCHEMBL319346 0.51 9/20
SCHEMBL5174856 SCHEMBL5174856 0.54 8/20
SCHEMBL4981012 SCHEMBL4981012 0.49 7/20
SCHEMBL4980255 SCHEMBL4980255 0.44 7/20
SCHEMBL2405204 SCHEMBL2405204 0.43 7/20
SCHEMBL7918480 SCHEMBL7918480 0.44 6/20
SCHEMBL4163734 SCHEMBL4163734 0.39 6/20
SCHEMBL3642571 SCHEMBL3642571 0.62 5/20
SCHEMBL22526 SCHEMBL22526 0.56 5/20
SCHEMBL658959 SCHEMBL658959 0.53 5/20
SCHEMBL8023521 SCHEMBL8023521 0.50 5/20
SCHEMBL2114738 SCHEMBL2114738 0.47 5/20
SCHEMBL5109866 SCHEMBL5109866 0.60 4/20
SCHEMBL859899 SCHEMBL859899 0.57 4/20
SCHEMBL383555 SCHEMBL383555 0.55 4/20
SCHEMBL7950791 SCHEMBL7950791 0.51 4/20
SCHEMBL273458 SCHEMBL273458 0.50 4/20
SCHEMBL3054255 SCHEMBL3054255 0.49 4/20
SCHEMBL7556755 SCHEMBL7556755 0.49 4/20

Clinical trials — most relevant to HSD17B14 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity PHASE4COMPLETED
Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone. PHASE4COMPLETED
Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians PHASE4UNKNOWN
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) PHASE3COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Neurosteroids for PTSD in Veterans PHASE2COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Mutation Analysis of 17βhydroxysteroid Dehydrogenase 3 Deficiency nanUNKNOWN
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole nanWITHDRAWN
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome nanCOMPLETED
Dose-response Effect of Alcohol Ingestion on Steroid Profile nanCOMPLETED
Pharmacogenetic Determinants Of Treatment Response In Children nanRECRUITING
Novel Biomarker for Development of T2D nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Androgens and NAFLD Longitudinal Cohort Study nanRECRUITING
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Tamoxifen Pharmacogenetics in Asian Breast Cancer Women nanUNKNOWN
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas nanUNKNOWN
Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease nanCOMPLETED
Epidemiology of Insulin and Dehydroepiandrosterone Sulfate and Coronary Heart Disease Mortality nanCOMPLETED
Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC) nanRECRUITING
Gene Polymorphisms Influencing Steroid Synthesis and Action nanWITHDRAWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension nanUNKNOWN
Final Height in Patients With CAH nanUNKNOWN
Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation nanUNKNOWN
Genetic Origin of Lipid Disorders nanUNKNOWN
A Pilot Study of Varying Doses of Tamoxifen in the Setting of Genetic Polymorphisms of CYP2D6 nanCOMPLETED
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC nanCOMPLETED
Biochemical and Genetic Markers in Liver Diseases nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HSD17B14 binder may also engage these)

ProteinNameSimilarity
E9Q3D4 — 0.999 E9Q3D4 →
A0A8I6GJ95 — 0.997 A0A8I6GJ95 →
Q9MYP6 — 0.996 Q9MYP6 →
A0A7T8F1N2 — 0.994 A0A7T8F1N2 →
P0C622 — 0.991 P0C622 →
E9QUT3 — 0.990 E9QUT3 →
Q9URX0 — 0.989 Q9URX0 →
P23102 — 0.989 P23102 →
Q8XBJ4 — 0.989 Q8XBJ4 →
P72220 — 0.989 P72220 →
P37440 — 0.989 P37440 →
A5W4G5 — 0.988 A5W4G5 →
E9ET40 — 0.988 E9ET40 →
P0A2D1 — 0.988 P0A2D1 →
P0A2D2 — 0.988 P0A2D2 →
P33368 — 0.988 P33368 →
A0A097ZPC9 — 0.988 A0A097ZPC9 →
P9WGQ2 — 0.987 P9WGQ2 →
A0A1L9WLH9 — 0.987 A0A1L9WLH9 →
Q9KJF1 — 0.987 Q9KJF1 →
P47227 — 0.987 P47227 →
P9WGQ4 — 0.987 P9WGQ4 →
A0A0B4GU97 — 0.986 A0A0B4GU97 →
Q6TMA3 — 0.986 Q6TMA3 →
A0A2I1C3T5 — 0.986 A0A2I1C3T5 →
A0A3G9HAL8 — 0.985 A0A3G9HAL8 →
P19871 — 0.985 P19871 →
P50206 — 0.985 P50206 →
P9WGQ3 — 0.985 P9WGQ3 →
C8WJW0 — 0.985 C8WJW0 →