Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432235 | 0.81 | SRD5A1 (0.32) | ALDH1A1SRD5A1 | |
| SCHEMBL6430811 | 0.80 | — | — | |
| SCHEMBL6431534 | 0.74 | SRD5A1 (0.35) | SRD5A1MEN1MAPTBRCA1KMT2A | |
| SCHEMBL6434510 | 0.73 | ALDH1A1 (0.37) | ALDH1A1SRD5A1KMT2A | |
| SCHEMBL6432674 | 0.71 | PSEN1 (0.31) | — | |
| SCHEMBL6435838 | 0.67 | SRD5A1 (0.48) | ALDH1A1SRD5A1MAPTKMT2A | |
| SCHEMBL6430969 | 0.67 | SRD5A1 (0.31) | SRD5A1 | |
| SCHEMBL6431384 | 0.65 | SRD5A1 (0.33) | SRD5A1 | |
| SCHEMBL23845132 | 0.61 | SRD5A1 (0.41) | ALDH1A1SRD5A1 | |
| SCHEMBL6431921 | 0.60 | ALDH1A1 (0.37) | ALDH1A1SRD5A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066284-B1 | BENZO(C)QUINOLIZINE DERIVATIVES AND THEIR USE AS 5 ALPHA-REDUCTASES INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2005-08-31 | — | — | EP | claimed |
| EP-0926148-A1 | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1999-06-30 | — | — | EP | claimed |
| US-6962925-B1 | Benzo(C)quinolizine derivatives and their use as 5α-reductases inhibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-11-08 | — | — | US | disclosed |
| EP-1066284-B1 | BENZO(C)QUINOLIZINE DERIVATIVES AND THEIR USE AS 5 ALPHA-REDUCTASES INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2005-08-31 | — | — | EP | disclosed |
| EP-0926148-A1 | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1999-06-30 | — | — | EP | disclosed |