Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 20/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 16/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 16/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 15/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 15/20 | 0.63 |
| ▸ | DRD2 | P14416 | 11/20 | 0.63 |
| ▸ | DRD4 | P21917 | 11/20 | 0.63 |
| ▸ | DRD3 | P35462 | 10/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435125 | 0.91 | CHRM1 (0.64) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6435446 | 0.88 | CHRM1 (0.63) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6438622 | 0.85 | CHRM1 (0.72) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6437575 | 0.85 | CHRM1 (0.48) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6439411 | 0.84 | CHRM1 (0.70) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4095226 | 0.80 | CHRM1 (0.74) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6436172 | 0.80 | CHRM1 (0.70) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4102515 | 0.80 | CHRM1 (0.66) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4101240 | 0.80 | CHRM1 (0.66) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4097774 | 0.79 | CHRM1 (0.75) | CHRM1CHRM5CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461318-B9 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-12-28 | — | — | EP | claimed |
| EP-1461318-B1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-09-14 | — | — | EP | claimed |