Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457342 | 0.84 | NAMPT (0.80) | NAMPTRAB9ANPC1CYP3A4CYP1A2 | |
| SCHEMBL349933 | 0.84 | NAMPT (0.80) | NAMPTRAB9ANPC1CYP3A4CYP1A2 | |
| SCHEMBL27532876 | 0.84 | KDM4E (0.51) | NAMPTRAB9ANPC1KMT2AP2RX7 | |
| SCHEMBL27658590 | 0.81 | CYP17A1 (0.50) | NAMPTRAB9ANPC1MEN1GAA | |
| SCHEMBL4254852 | 0.80 | GAA (0.60) | RAB9ANPC1MEN1GAAKMT2A | |
| SCHEMBL19318495 | 0.80 | TSHR (0.58) | NAMPTRAB9ANPC1GAAP2RX7 | |
| SCHEMBL22770010 | 0.79 | GAA (0.46) | NAMPTRAB9ANPC1MEN1GAA | |
| SCHEMBL6260359 | 0.77 | NAMPT (0.69) | NAMPTRAB9ANPC1CYP3A4CYP1A2 | |
| SCHEMBL7088891 | 0.77 | NAMPT (0.55) | NAMPTRAB9AGAASMN1; SMN2LMNA | |
| SCHEMBL19322921 | 0.77 | CYP3A4 (0.60) | NAMPTRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109942575-A | Pyrrolopyridine as kinase inhibitor | 阵列生物制药公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-104926810-B | Pyrrolopyridine as kinase inhibitor | 阵列生物制药公司 | 2019-02-19 | — | — | CN | disclosed |
| CN-102307871-A | Isoindolinone and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-01-04 | — | — | CN | disclosed |
| CN-101855222-A | Imidazol (1,2-A)pyridines and related compounds with activity at cannabinoid CB2 receptors | GE HEALTHCARE LTD | 2010-10-06 | — | — | CN | disclosed |
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |