Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951394 | 0.81 | LRRK2 (0.39) | PDE4BPDE7AMAPK1ALDH1A1PDE1A | |
| SCHEMBL4954967 | 0.75 | PDE1B (0.42) | BRD4PDE1APDE1BPDE1CLRRK2 | |
| SCHEMBL4952368 | 0.75 | PDE1B (0.42) | BRD4PDE1APDE1BPDE1CLRRK2 | |
| SCHEMBL4330507 | 0.74 | PDE4B (0.41) | PDE4BPDE7APDE3BPDE3APOLB | |
| SCHEMBL4951461 | 0.71 | LRRK2 (0.44) | PDE4BBRD4PDE7AMAPK1PDE1B | |
| SCHEMBL4931029 | 0.70 | ADORA2A (0.39) | ALDH1A1POLB | |
| SCHEMBL5176743 | 0.70 | PDE4B (0.39) | PDE4BBRD4PDE7AMAPK1PDE1B | |
| SCHEMBL2250305 | 0.69 | CCNE2 (0.39) | — | |
| SCHEMBL4937428 | 0.67 | ROCK2 (0.42) | BRD4MAPK1ALDH1A1POLB | |
| SCHEMBL3429048 | 0.67 | PDE4B (0.57) | PDE4BPDE7APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |